Role in Neuroprotection

Role in Neuroprotection

  • Cannabidiol and the cannabinoid signaling pathway within the nervous system is involved in key aspects of both neuroprotection and remyelination, which is the most common regenerative process that occurs within the brain, and can have beneficial effects on the central nervous system (CNS), peripheral nervous system (PNS), and also the enteric nervous system (ENS, the gut’s nervous system).
  • Cannabinoid signaling molecules in the brain have been shown to be involved in oligodendrocyte maturation, which is a process thought to be critical for brain repair after being damaged by the immune system during multiple sclerosis (Gomez et. al., 2010).
  • Cannabidiol has been shown to been shown to protect oligodendrocyte progenitor cells, or OPCs, which are the cells that are critical for brain repair in multiple sclerosis.  In addition, it does this through methods that are entirely independent of the traditional cannabinoid signaling pathway, meaning it may exert beneficial effects in more ways than one (Mecha et. al., 2012).

“CBD… represents a rare, if not unique, compound that is capable of affording neuroprotection by the combination of different types of properties e.g., anti-glutamatergic effects, anti-inflammatory action, and antioxidant effects”
Iuvone et. al., 2009

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